Onder andere met: Annette Bening (Deirdre Burroughs), Brian Cox (Dr. Finch), Joseph Fiennes (Neil Bookman), Evan Rachel Wood (Natalie Finch), Alec Baldwin (Norman Burroughs), Joseph Cross (Augusten Burroughs), Jill Clayburgh (Agnes Finch), Gwyneth Paltrow (Hope Finch), Gabrielle Union (Dorothy), Patrick Wilson (Michael Shephard), Kristin Chenoweth (Fern Stewart), Dagmara Dominczyk (Suzanne), Colleen Camp (Joan), Jack Kaeding (Six-Year-Old Augusten Burroughs), Gabriel Guedj (Poo)