Onder andere met: Jake Gyllenhaal (Donnie Darko), Holmes Osborne (Eddie Darko), Maggie Gyllenhaal (Elizabeth Darko), Daveigh Chase (Samantha Darko), Mary McDonnell (Mrs. Rose Darko), James Duval (Frank), Arthur Taxier (Dr. Fisher), Patrick Swayze (Jim Cunningham), Mark Hoffman (Police Officer), David St. James (Bob Garland), Tom Tangen (Man in Red Jogging Suit), Jazzie Mahannah (Joanie James), Jolene Purdy (Cherita Chen), Stuart Stone (Ronald Fisher), Gary Lundy (Sean Smith)