Onder andere met: Owen Wilson (Lightning McQueen (voice)), Paul Newman (Doc Hudson (voice)), Bonnie Hunt (Sally Carrera (voice)), Larry The Cable Guy (Mater (voice)), Cheech Marin (Ramone (voice)), Tony Shalhoub (Luigi (voice)), Guido Quaroni (Guido (voice)), Jenifer Lewis (Flo (voice)), Paul Dooley (Sarge (voice)), Michael Wallis (Sheriff (voice)), George Carlin (Fillmore (voice)), Katherine Helmond (Lizzie (voice)), John Ratzenberger (Mack/Hamm Truck/Abominable Snow Plow/P.T. Flea Car (voice)), Joe Ranft (Red/Peterbilt (voice)), Michael Keaton (Chick Hicks (voice)), Richard Petty (The King), Jeremy Piven (Harv)