Onder andere met: Tobin Bell (John Cramer/Jigsaw), Shawnee Smith (Amanda), Angus Macfadyen (Jeff), Bahar Soomekh (Dr. Lynn Denlon), Dina Meyer (Kerry), Donnie Wahlberg (Eric Matthews), Mpho Koaho (Tim), Barry Flatman (Judge Halden), Lyriq Bent (Rigg), J. LaRose (Troy), Debra McCabe (Denica Scott (as Debra Lynne McCabe)), Costas Mandylor (Forensic Hoffman), Betsy Russell (Jill), Jane Luk (Nurse (Emergency Room)), Stefan Georgiou (Dylan)