Onder andere met: Woody Harrelson (Larry Flynt), Courtney Love (Althea Leasure), Edward Norton (Alan Isaacman), Brett Harrelson (Jimmy Flynt), Donna Hanover (Ruth Carter Stapleton), James Cromwell (Charles Keating), Crispin Glover (Arlo), Vincent Schiavelli (Chester), Miles Chapin (Miles), James Carville (Simon Leis), Richard Paul (Jerry Falwell), Burt Neuborne (Roy Grutman), Jan Triska (The Assassin), Cody Block (10-Year-Old Larry), Ryan Post (8-Year-Old Jimmy)