Onder andere met: Sheryl Lee (Laura Palmer), Ray Wise (Leland Palmer), Mädchen Amick (Shelly Johnson (as Madchen Amick)), Dana Ashbrook (Bobby Briggs), Phoebe Augustine (Ronette Pulaski), David Bowie (Phillip Jeffries), Eric DaRe (Leo Johnson), Miguel Ferrer (FBI Agent Albert Rosenfield), Pamela Gidley (Teresa Banks), Heather Graham (Annie Blackburn), Chris Isaak (FBI Special Agent Chester Desmond), Moira Kelly (Donna Hayward), Peggy Lipton (Norma Jennings), David Lynch (FBI Regional Bureau Chief Gordon Cole), James Marshall (James Hurley)