Onder andere met: Gerard Butler (Dracula), Christopher Plummer (Abraham/Matthew Van Helsing), Jonny Lee Miller (Simon Sheppard), Justine Waddell (Mary Heller), Colleen Fitzpatrick (Lucy Westerman (as Colleen Anne Fitzpatrick)), Jennifer Esposito (Solina), Omar Epps (Marcus), Sean Patrick Thomas (Trick), Danny Masterson (Nightshade), Lochlyn Munro (Eddie), Tig Fong (Dax), Tony Munch (Charlie), Jeri Ryan (Valerie Sharpe), Shane West (J.T.), Nathan Fillion (Father David)