Onder andere met: Rachel McAdams (Lisa Reisert), Cillian Murphy (Jackson "Jake" Rippner), Brian Cox (Joe Reisert), Laura Johnson (Blonde Woman), Max Kasch (Headphone Kid), Jayma Mays (Cynthia), Angela Paton (Nice Lady), Suzie Plakson (Senior Flight Attendant), Jack Scalia (Charles Keefe), Teresa Press-Marx (Marianne Taylor), Robert Pine (Bob Taylor), Carl Gilliard (Taxi Driver), Mary Kathleen Gordon (Airline Representative (as Mary-Kathleen Gordon)), Loren Lester (Irate Passenger), Philip Pavel (Dallas Ticket Agent), Brittany Oaks (Rebecca)