Onder andere met: Joaquin Phoenix (Johnny Cash), Reese Witherspoon (June Carter), Ginnifer Goodwin (Vivian Cash), Robert Patrick (Ray Cash), Dallas Roberts (Sam Phillips), Dan John Miller (Luther Perkins), Larry Bagby (Marshall Grant), Shelby Lynne (Carrie Cash), Tyler Hilton (Elvis Presley), Waylon Payne (Jerry Lee Lewis (as Waylon Malloy Payne)), Shooter Jennings (Waylon Jennings), Sandra Ellis Lafferty (Maybelle Carter), Dan Beene (Ezra Carter), Clay Steakley (W.S. `Fluke` Holland), Johnathan Rice (Roy Orbison)